BEBAC  Ing. Helmut Schütz


This series of articles was inspired by recurrent discussions at the Bio­equi­va­lence and Bio­avail­ability Forum and questions I received from regulatory assessors or my clients.

The true Enlightenment thinker, the true rationalist,
never wants to talk anyone into anything.
No, he does not even want to convince;
all the time he is aware that he may be wrong.
– Karl R. Popper

To the right articles are listed in chronological order. Below are articles arranged by topic.

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Power Calculation and Sample Size Estimation


Non-Inferiority, Non-Superiority

Dose Proportionality 🚧

Prospective Power

Noncompartmental Analysis



Design Issues


Those people who think they know everything
are a great annoyance to those of us who do.
– Isaac Asimov

All articles are licensed under CC BY 4.0 Creative Commons Attribution 4.0 Helmut Schütz 2021.